Biodegradable polymerized simvastatin stimulates bone formation
نویسندگان
چکیده
منابع مشابه
Does simvastatin stimulate bone formation in vivo?
BACKGROUND Statins, potent compounds that inhibit cholesterol synthesis in the liver have been reported to induce bone formation, both in tissue culture and in rats and mice. To re-examine potential anabolic effects of statins on bone formation, we compared the activity of simvastatin (SVS) to the known anabolic effects of PTH in an established model of ovariectomized (OVX) Swiss-Webster mice. ...
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Cathepsin K (CTSK) is secreted by osteoclasts to degrade collagen and other matrix proteins during bone resorption. Global deletion of Ctsk in mice decreases bone resorption, leading to osteopetrosis, but also increases the bone formation rate (BFR). To understand how Ctsk deletion increases the BFR, we generated osteoclast- and osteoblast-targeted Ctsk knockout mice using floxed Ctsk alleles. ...
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2019
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2019.04.059